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. 2015 Jul 7;49(13):8105-12.
doi: 10.1021/acs.est.5b01854. Epub 2015 Jun 18.

Human Serum from Urban and Rural Adolescents and Their Mothers Shows Exposure to Polychlorinated Biphenyls Not Found in Commercial Mixtures

Wen Xin Koh  1 , Keri C Hornbuckle  1 , Peter S Thorne  1
Affiliations

Human Serum from Urban and Rural Adolescents and Their Mothers Shows Exposure to Polychlorinated Biphenyls Not Found in Commercial Mixtures

Wen Xin Koh et al. Environ Sci Technol. .

Abstract

Although polychlorinated biphenyls are no longer sold as commercial mixtures, they are still being produced through modern manufacturing processes. We have previously shown that non-Aroclor PCB 11 is prevalent in indoor and outdoor air and sediment and detected in human serum. Here we report the prevalence of non-Aroclor PCB congeners (≤0.20 wt % in Aroclor) in human serum collected from urban and rural adolescents and their mothers. We hypothesized that additional non-Aroclor congeners are present in serum. Sera were extracted and detected for 209 PCBs using gas chromatography-tandem mass spectrometry. A list of 70 non-Aroclor PCB congeners was determined by measurement of original Aroclors. PCB 11, 14, 35, and 209 are the major dominating and most frequently detected congeners. PCB 14 and 35 have not been previously reported for environmental matrices. Adolescents have significantly lower total non-Aroclor PCB concentrations than mothers in East Chicago (p < 0.001) and Columbus Junction (p = 0.008). There are significant differences in non-Aroclor PCBs between East Chicago community and Columbus Junction community (p < 0.001). Non-Aroclor PCBs represent an average of 10% (and up to 50%) of total PCBs measured in serum. An average of 50% (and up to 100%) of these concentrations may be attributed to aryl azo and phthalocyanine paint pigments.

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Figures

Figure 1
Figure 1
Detection frequency of each non-Aroclor PCB congener in adolescents and their mothers in East Chicago and Columbus Junction. (Bars indicate proportion of the total 175 participants)
Figure 2
Figure 2
Non-Aroclor PCB congener profile of adolescents and their mothers in East Chicago and Columbus Junction.
Figure 3
Figure 3
Ratio of sum 70 non-Aroclor PCB congeners to sum 209 PCB congeners (a) and sum 10 non-Aroclor PCB congeners in paint to sum 70 non-Aroclor PCB congeners (b) in adolescents and their mothers in East Chicago and Columbus Junction. (Dash line represents mean line)
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