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. 2015 Jun 9:16:80.
doi: 10.1186/s12882-015-0081-x.

End stage renal disease as a modifier of the periodontal microbiome

Michel V Furtado Araújo  1 , Bo-Young Hong  2 , Philip L Fava  3 , Shiza Khan  4 , Joseph A Burleson  5 , George Fares  6 , Wilner Samson  7 , Linda D Strausbaugh  8 , Patricia I Diaz  9 , Effie Ioannidou  10
Affiliations

End stage renal disease as a modifier of the periodontal microbiome

Michel V Furtado Araújo et al. BMC Nephrol. .

Abstract

Background: Evidence supports high prevalence of periodontitis in patients with chronic kidney disease. Several renal factors have been proposed as possible modifiers of periodontitis pathogenesis in this population. In this cross sectional study, we investigated whether distinct microbial profiles in renal patients could explain high periodontitis prevalence.

Methods: We characterized the subgingival microbiome in 14 End Stage Renal Disease (ESRD) and 13 control individuals with chronic periodontitis with similar demographic and clinical parameters. Medical, demographic and periodontal parameters were recorded. Subgingival biofilm samples were collected from the deepest pocket in two different quadrants and characterized via 454-pyrosequencing of the 16S rRNA gene.

Results: We found 874 species-level operational taxonomic units (OTU) across samples. Renal and control groups did not differ in the individual proportions of periodontitis-associated taxa. However, in principal coordinate plots of distance among samples based on OTU prevalence, some renal patients clustered apart from controls, with the microbial communities of these outlier subjects showing less diversity. Univariate correlation analysis showed a significant negative correlation between dialysis vintage and community diversity.

Conclusions: Within the study limitations, dialysis vintage was associated with a less diverse periodontal microbial community in ESRD suggesting the need for further research.

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Figures

Fig. 1
Fig. 1
a: Difference in β-diversity in ESRD and Control samples. The plot was based on the θYC index, which measures distance among samples according to community structure. b: β-diversity comparisons (arrows indicate the ESRD-O samples). The plot was based on the Jaccard Index, which measures distance among samples according to taxa prevalence. c: Relative abundance of individual taxa. Individual OTUs with different relative proportion in ESRD (red bards) and Control groups (green bars). Differences in relative abundances were determined with LEfSe
See this image and copyright information in PMC

References

    1. Ioannidou E, Swede H, Dongari-Bagtzoglou A. Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease. J Dent Res. 2011;90(12):1411–5. doi: 10.1177/0022034511423394. - DOI - PMC - PubMed
    1. Ioannidou E, Swede H, Fares G, Himmelfarb J. Tooth loss strongly associates with malnutrition in chronic kidney disease. J Periodontol. 2014;85(7):899–907. doi: 10.1902/jop.2013.130347. - DOI - PMC - PubMed
    1. Fisher MA, Taylor GW. A prediction model for chronic kidney disease includes periodontal disease. J Periodontol. 2009;80(1):16–23. doi: 10.1902/jop.2009.080226. - DOI - PMC - PubMed
    1. Fisher MA, Taylor GW, Papapanou PN, Rahman M, Debanne SM. Clinical and serologic markers of periodontal infection and chronic kidney disease. J Periodontol. 2008;79(9):1670–8. doi: 10.1902/jop.2008.070569. - DOI - PubMed
    1. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ. Prevalence of Periodontitis in Adults in the United States: 2009 and 2010. J Dent Res. 2012;91(10):914–20. doi: 10.1177/0022034512457373. - DOI - PubMed

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