Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 15:100:1-9.
doi: 10.1016/j.ejmech.2015.05.043. Epub 2015 May 30.

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities

Rakesh Chopra  1 , Carmen de Kock  2 , Peter Smith  2 , Kelly Chibale  3 , Kamaljit Singh  4
Affiliations

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities

Rakesh Chopra et al. Eur J Med Chem. .

Abstract

The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied.

Keywords: Antiplasmodial studies; Ferrocene conjugates; Ferrocene/ferrocenium redox couple; Huisgen 1,3-dipolar cycloaddition; Lipophilicity.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources