Host cell targets for African swine fever virus

Abstract

Viruses are strict intracellular pathogens that require the cellular environment to complete a successful infection. Among them, African swine fever virus (ASFV) is an evolutionary ancient DNA virus, endemic in Africa, which is nowadays causing an emergent disease in Europe with a potential high economic impact in the pig industry. It is well known that host-cell components are critical crossroads mapping the virus path for a productive infection, some of them at the endocytic pathway. Considering that ASFV infectious cycle strongly relies in several factors from the host cell, the study of virus-host interactions remains crucial as they will reveal the obstacles, routes and tracks, hints and the target waypoint in the virus journey to destination.

Keywords: African swine fever virus; Aggresomes; BAG3; Cholesterol; Endocytosis; HDAC6; Host cell targets; Phosphatidylinositol phosphates and kinases; Viral factories; Virus entry.