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Comment
. 2015 Jun 8;27(6):745-6.
doi: 10.1016/j.ccell.2015.05.011.

T-ALL: Home Is where the CXCL12 Is

Charles E de Bock  1 , Jan Cools  2
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T-ALL: Home Is where the CXCL12 Is

Charles E de Bock et al. Cancer Cell. .
Free article

Abstract

T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these mutations, Passaro and colleagues and Pitt and colleagues in this issue of Cancer Cell demonstrate that T-ALL initiating cells residing in bone marrow depend on the CXCR4/CXCL12 signaling axis for disease maintenance and progression.

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