Excluding T Cells: Is β-Catenin the Full Story?

Siwen Hu-Lieskovan¹, Blanca Homet Moreno², Antoni Ribas³

Affiliations

¹ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA.
² Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
³ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Surgery, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Medical and Molecular Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA. Electronic address: aribas@mednet.ucla.edu.

PMID: 26058073
DOI: 10.1016/j.ccell.2015.05.014

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Excluding T Cells: Is β-Catenin the Full Story?

Siwen Hu-Lieskovan et al. Cancer Cell. 2015.

Free article

. 2015 Jun 8;27(6):749-50.

doi: 10.1016/j.ccell.2015.05.014.

Authors

Siwen Hu-Lieskovan¹, Blanca Homet Moreno², Antoni Ribas³

Affiliations

¹ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA.
² Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
³ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Surgery, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Medical and Molecular Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA. Electronic address: aribas@mednet.ucla.edu.

PMID: 26058073
DOI: 10.1016/j.ccell.2015.05.014

Abstract

Spranger and colleagues reported recently in Nature an inverse relationship between melanoma intrinsic β-catenin signaling and intratumoral T cell infiltration, providing an explanation for potential mechanisms of T cell exclusion. Further insights are needed into the mechanisms leading to a lack of T cell infiltration of cancers and primary immune resistance.

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Spranger S, Bao R, Gajewski TF. Spranger S, et al. Nature. 2015 Jul 9;523(7559):231-5. doi: 10.1038/nature14404. Epub 2015 May 11. Nature. 2015. PMID: 25970248

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Excluding T Cells: Is β-Catenin the Full Story?

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Excluding T Cells: Is β-Catenin the Full Story?

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Medical

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