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. 2015 Jun 8;27(6):751-3.
doi: 10.1016/j.ccell.2015.05.012.

The Next Wave of EGFR Tyrosine Kinase Inhibitors Enter the Clinic

Katerina Politi  1 , Deborah Ayeni  2 , Thomas Lynch  3
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Free article

The Next Wave of EGFR Tyrosine Kinase Inhibitors Enter the Clinic

Katerina Politi et al. Cancer Cell. .
Free article

Abstract

The T790M mutation in EGFR accounts for approximately half of all lung cancer cases with acquired resistance to the current clinical EGFR tyrosine kinase inhibitors. In tyrosine kinase inhibitor-resistant lung tumors, rociletinib and AZD9291 are highly active when T790M is present and modestly active when T790M is absent.

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