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Case Reports
. 2015 Apr-Jun;13(2):276-8.
doi: 10.1590/S1679-45082015RC2952. Epub 2015 Jun 9.

Aggressive angiomyxoma of the vulva: case report

[Article in English, Portuguese]
José Carlos Castelo Branco Ribeiro  1 , Sabas Carlos Vieira  2 , Benedito Borges da Silva  2 , Lina Gomes dos Santos  2 , Pedro Vítor Lopes Costa  2 , Lia Andréa Costa da Fonsêca  2
Affiliations
Case Reports

Aggressive angiomyxoma of the vulva: case report

[Article in English, Portuguese]
José Carlos Castelo Branco Ribeiro et al. Einstein (Sao Paulo). 2015 Apr-Jun.

Abstract
in English, Portuguese

Female patient, 42-years-old, complaining of difficulty in urinating and swelling in the vulvar area for one year. Her gynecological examination showed extensive injury in the vulvar region and the biopsy done was inconclusive. The removal of the lesion was conducted. After the procedure, the patient remains free of recurrence for 15 months. This case highlights the need to consider angiomyxoma in the differential diagnosis for tumors of unknown cause in the vulvar region.

Paciente do gênero feminino, 42 anos, com queixas de dificuldade ao urinar e aumento de volume na região vulvar há 1 ano. Ao exame ginecológico, apresentava extensa lesão na região vulvar. Biópsia da lesão foi inconclusiva. Realizou-se a exérese da lesão. A paciente permanece livre de recorrências há 15 meses. Este caso destaca a necessidade de considerar o angiomixoma no diagnóstico diferencial de massas de causa desconhecida na região vulvar.

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Figures

Figure 1
Figure 1. Pre-operative appearance. Large mass located in perineal and vulvar region
Figure 2
Figure 2. Macroscopic appearance of tumors, which measured 18x11x13cm with undulating external surface and grayish-white, and lobulated cut surface, brilliant and grayish-white with myxoid areas
Figure 3
Figure 3. Microscopic appearance of the tumor. Vessels of medium size and thickened wall, involved by stromal cell layer of myxoid apperance. Hematoxylin and eosin 200X
Figura 1
Figura 1. Aparência pré-operatória. Volumosa massa localizada na região perineal e vulvar
Figura 2
Figura 2. Aparência macroscópica do tumor, cujas dimensões eram 18x11x13cm, com superfície externa ondulada e branco-acinzentada, e superfície de corte lobulada, brilhante e branco-acizentada com áreas mixoides
Figura 3
Figura 3. Aparência microscópica do tumor. Vasos de tamanho médio e parede espessada, circundados por uma camada de células estromais de aparência mixoide. Hematoxilina e eosina 200X
See this image and copyright information in PMC

References

    1. Fetsch JF, Laskin WB, Lefkowitz M, Kindblom LG, Meis-Kindblom JM. Aggressive angiomyxoma: a clinicopathologic study of 29 female patients. Cancer. 1996;78(1):79–90. - PubMed
    1. Nucci MR, Weremowicz S, Neskey DM, Sornberger K, Tallini G, Morton CC, et al. Chromosomal translocation t (8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva. Genes Chromosomes Cancer. 2001;32(2):172–176. - PubMed
    1. Haldar K, Martinek IE, Kehoe S. Aggressive angiomyxoma: a case series and literature review. Eur J Surgical Oncol. 2010;36(4):335–339. Review. - PubMed
    1. Faber B, Dunwoody R, Kamal N. A rarer case of a rare disease: aggressive angiomyxoma (AAM) in a sixteen year old. West London Med J. 2013;5(1):1–5.
    1. Gonzaga LF, Freitas FC, Tavares JM. Aggressive vaginal angiomyxoma mimicking urethral tumor. Int Braz J Urol. 2005;31(5):475–476. - PubMed

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