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. 2015 Jun 10;13(1):9.
doi: 10.1186/s12948-015-0015-y. eCollection 2015.

T helper cell mediated-tolerance towards fetal allograft in successful pregnancy

Marie-Pierre Piccinni  1 , Letizia Lombardelli  1 , Federica Logiodice  1 , Ornela Kullolli  1 , Sergio Romagnani  1 , Philippe Le Bouteiller  2
Affiliations

T helper cell mediated-tolerance towards fetal allograft in successful pregnancy

Marie-Pierre Piccinni et al. Clin Mol Allergy. .

Abstract

Trophoblast HLA-C antigens from paternal origins, which liken the trophoblast to a semiallograft, could be presented by the maternal APCs to the specific maternal CD4+ T helper cells, which could release various cytokines in response to these alloantigens. On the basis of the cytokines produced, these cells can be classified in Th1, Th2 and Th17 cells. Th1 and Th17 cells, known to be responsible for acute allograft rejection, could be involved in miscarriage and Th2 cells together with regulatory CD4+ T cells, known to be involved in allograft tolerance, could be responsible, at least in part, for the success of pregnancy. In this review we focus the role effector CD4+ T cells Th1, Th2 and Th17 cells on the fetal allograft tolerance.

Keywords: Abortion; Allograft; Pregnancy; T helper cells; Th1; Th17; Th2.

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