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. 2015 Mar 15;8(3):3817-24.
eCollection 2015.

Association between Fas/FasL polymorphism and susceptibility to leukemia: a meta-analysis

Yiran Chen  1 , Yiho He  1 , Xiaotong Lu  1 , Zhirui Zeng  1 , Chen Tang  1 , Tongyuan Xue  2 , Yuhua Li  2
Affiliations

Association between Fas/FasL polymorphism and susceptibility to leukemia: a meta-analysis

Yiran Chen et al. Int J Clin Exp Med. .

Abstract

The polymorphisms in Fas/FasL system were proposed to be associated with susceptibility to leukemia, but recent studies reported controversial findings. Hence, we performed a meta-analysis to assess the association between Fas gene polymorphisms and susceptibility to leukemia. We carried out a literature search in PubMed, Embase, Web of Science and CNKI databases for studies on the associations between Fas/FasL gene polymorphisms and susceptibility to leukemia. The associations were assessed by odds ratio (OR) together with its 95% confidence intervals (CIs). 7 literatures and 14 studies with a total of 8787 subjects were eventually included into our meta-analysis. Overall, there was no association between Fas/FasL polymorphisms and susceptibility to leukemia. In subgroup analysis by ethnicity, there was also no association between Fas/FasL polymorphisms and susceptibility to leukemia in Asians and Caucasians. In addition, there was also a significant association between Fas-1377G/A polymorphism and susceptibility to leukemia in ALL patients, the A allele seemed to be a protective factor in ALL risk. In summary, more studies with large sample size are needed to provide further evidence for association between Fas/FasL polymorphisms and susceptibility to leukemia.

Keywords: Leukemia; meta-analysis; polymorphism.

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Figures

Figure 4
Figure 4
Funnel plots between Fas polymorphisms and leukemia risk. A. GG vs AG/AA (Fas-670); B. AA vs GA/GG (CC vs TC/TT).
Figure 1
Figure 1
Meta-Analysis of association between Fas-670 polymorphism and susceptibility to leukemia (GG vs AG/AA).
Figure 2
Figure 2
Meta-Analysis of association between Fas-1377 polymorphism and susceptibility to leukemia (AA vs GA/GG).
Figure 3
Figure 3
Meta-Analysis of association between FasL-844 polymorphism and susceptibility to leukemia (CC vs TC/TT).
See this image and copyright information in PMC

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