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. 1979 Oct;16(4):458-62.
doi: 10.1128/AAC.16.4.458.

In vitro response of Enterobacter to ampicillin

M F Lampe, B H Minshew, J C Sherris

In vitro response of Enterobacter to ampicillin

M F Lampe et al. Antimicrob Agents Chemother. 1979 Oct.

Abstract

Three strains of Enterobacter were studied for their response to ampicillin. They exhibited a basic level of resistance that depended on the medium used and high-level mutational resistance at a frequency of 10(-5) to 10(-7). Two classes of mutants were selected, one of which showed markedly enhanced antibiotic inactivation as indicated by a biological assay and the other of which resembled the wild type in this regard. Both mutants showed cross-resistance to other beta-lactam antibiotics. The results explained discrepancies between traditional broth dilution minimum inhibitory concentration tests and early read automated procedures.

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References

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