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Editorial
. 2015;14(16):2541-2.
doi: 10.1080/15384101.2015.1060774. Epub 2015 Jun 11.

KM mutant highlights enhancers in minor ZGA

Yuki Okada  1 , Keisuke Aoshima
Affiliations
Editorial

KM mutant highlights enhancers in minor ZGA

Yuki Okada et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
After fertilization, a paternal PN gradually establishes new epigenetic marks. In the middle pronuclear stage, newly synthesized Mll3/4 introduces H3K4me1 predominantly in paternal PNs, and it triggers transcriptional activation corresponding to minor ZGA from paternal genome. Since Mll3/4 preferentially mono-methylates H3K4 at enhancers rather than promoters, it suggests the importance of enhancer activation in the onset of paternal minor ZGA.M
See this image and copyright information in PMC

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