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Comment
. 2015 Jun 10;17(6):733-5.
doi: 10.1016/j.chom.2015.05.017.

Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

Laleh Majlessi  1 , Roland Brosch  2
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Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity

Laleh Majlessi et al. Cell Host Microbe. .
Free article

Abstract

The intracellular fate of Mycobacterium tuberculosis is a subject of long debate. In this issue of Cell Host & Microbe, three independent studies reveal the detection of cytosolic mycobacterial DNA by the nucleotidyltransferase cGAS, emphasizing the concept of cytosolic access by M. tuberculosis and its role in balancing immune-protection and immune-pathogenesis.

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