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Comment
. 2015 Jun 12;348(6240):1217.
doi: 10.1126/science.aaa8299. Epub 2015 Jun 11.

LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling"

Calvin H Jan  1 , Christopher C Williams  1 , Jonathan S Weissman  2
Affiliations
Comment

LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling"

Calvin H Jan et al. Science. .

Abstract

Reid and Nicchitta propose that most cellular translation is carried out by a noncycling pool of endoplasmic reticulum (ER)-associated ribosomes. However, proximity-specific ribosome profiling data place an upper bound of about 7 to 16% on the fraction of cytosolic protein translation carried out by ribosomes accessible to ER-tethered biotin ligases. Moreover, yeast pulse-labeling experiments argue against there being a static population of ER-associated ribosomes.

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