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. 2010 Oct;1(4):320-7.
doi: 10.1177/1947603510376820.

Comparison between Platelet-Rich Plasma and Autologous Iliac Grafts for Tibial Osteotomy

Caio Oliveira D'Elia  1 , Márcia Uchôa de Rezende  1 , Alexandre Carneiro Bitar  2 , Nelson Tatsui  1 , José Ricardo Pécora  1 , Arnaldo José Hernandez  1 , Gilberto Luis Camanho  1
Affiliations

Comparison between Platelet-Rich Plasma and Autologous Iliac Grafts for Tibial Osteotomy

Caio Oliveira D'Elia et al. Cartilage. 2010 Oct.

Abstract

Objective: Platelet-rich plasma (PRP) has the capacity to improve the bone-healing process. The aim of this pilot study was to investigate the occurrence of bone healing and the time taken to achieve this in patients submitted to medial opening wedge high tibial osteotomy (MOWHTO), comparing platelet-rich plasma with bone marrow aspirate to autologous iliac graft.

Design: Twenty-five patients who underwent tibial osteotomy were randomly divided into 2 groups: a control group, which received autologous iliac grafts (14 patients), and a study group, which received a compound of PRP and bone marrow aspirate (11 patients).

Results: The bone-healing rates achieved were 100% in the control group and 91% in the study group. There was no difference in the time taken to achieve bone healing between the groups.

Conclusions: The use of a combination of PRP and bone marrow aspirate, as a bone substitute, did not demonstrate any advantage over the use of an autologous iliac graft in MOWHTO.

Keywords: bone marrow; bone substitutes; knee; osteotomy; platelet-rich plasma.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1.
Figure 1.
Radiographic criteria used to access bone healing.
Figure 2.
Figure 2.
Example of union in an osteotomy performed in a 45-year-old patient with a 12.5-mm wedge, 12 weeks to bone healing.
Figure 3.
Figure 3.
Example of nonunion in an osteotomy performed in a 37-year-old patient with a 12.5-mm wedge, 24 weeks until considered a nonunion.
Figure 4.
Figure 4.
Dispersion graph showing time for bone healing versus patient age.
Figure 5.
Figure 5.
Kaplan-Meier estimates for the autologous iliac and platelet-rich plasma (PRP) groups. The + represents the occurrence of a censure.
Figure 6.
Figure 6.
Radiographs after bone healing of patients with anterior cruciate ligament chronic injuries submitted to tibial opening wedge osteotomy: the 1st patient (A) is a 53-year-old male with a 15-mm wedge evaluated 14 weeks after receiving autologous iliac graft. The 2nd patient (B) is a 34-year-old woman with a 12.5-mm wedge evaluated 8 weeks after receiving a compound of platelet-rich plasma and bone marrow aspirate.
See this image and copyright information in PMC

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