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. 2014 Jul;5(3):145-53.
doi: 10.1177/1947603514529445.

Autologous Matrix-Induced Chondrogenesis in the Knee: A Review

Yee Han Dave Lee  1 , Ferzan Suzer  2 , Hajo Thermann  2
Affiliations

Autologous Matrix-Induced Chondrogenesis in the Knee: A Review

Yee Han Dave Lee et al. Cartilage. 2014 Jul.

Abstract

Objective: Autologous matrix-induced chondrogenesis (AMIC) is a 1-step cartilage restoration technique that combines microfracture with the use of an exogenous scaffold. This matrix covers and mechanically stabilizes the clot. There have been an increasing number of studies performed related to the AMIC technique and an update of its use and results is warranted.

Design and methods: Using the PubMed database, a literature search was performed using the terms "AMIC" or "Autologous Matrix Induced Chondrogenesis." A total of 19 basic science and clinical articles were identified.

Results: Ten studies that were published on the use of AMIC for knee chondral defects were identified and the results of 219 patients were analyzed. The improvements in Knee Injury and Osteoarthritis Outcome Score, International Knee Documentation Committee Subjective, Lysholm and Tegner scores at 2 years were comparable to the published results from autologous chondrocyte implantation (ACI) and matrix ACI techniques for cartilage repair.

Conclusions: Our systematic review of the current state of the AMIC technique suggests that it is a promising 1-stage cartilage repair technique. The short-term clinical outcomes and magnetic resonance imaging results are comparable to other cell-based methods. Further studies with AMIC in randomized studies versus other repair techniques such as ACI are needed in the future.

Keywords: autologous matrix-induced chondrogenesis (AMIC); cartilage; microfracture.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Preparation of the defect with stable shoulders around the defect.
Figure 2.
Figure 2.
Subchondral drilling with K-wires.
Figure 3.
Figure 3.
Preparing the ChondroGide matrix prior to implantation. Note the dots placed on the surface to indicate the nonporous side (ie, the side not on bone).
Figure 4.
Figure 4.
Defect covered with the ChondroGide matrix.
Figure 5.
Figure 5.
Femoral condyle defect with a ChondroGide matrix.
See this image and copyright information in PMC

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