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. 2013 Dec;6(6):639-42.
doi: 10.1093/ckj/sft124. Epub 2013 Nov 4.

Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy

Camilla Aakjær Andersen  1 , Niels Marcussen  2 , Jon Waarst Gregersen  1
Affiliations

Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy

Camilla Aakjær Andersen et al. Clin Kidney J. 2013 Dec.

Abstract

Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway of complement. In previously reported cases of MPGN and C3 GN secondary to monoclonal gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the first patient, to our knowledge, who showed full renal recovery and normalization of the complement system after chemotherapy and stem cell transplantation.

Keywords: C3 glomerulonephritis; membranoproliferative glomerulonephritis; monoclonal gammopathy.

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Figures

Fig. 1.
Fig. 1.
Renal biopsy. (a) Membranoproliferative glomerulonephritis, Periodic Acid Schiff ×200; (b) immunofluorescence for C3, ×200; (c) immunofluorescence for kappa light chain, ×200; (d) electron microscopy demonstrating splitting of the glomerular basement membrane and deposits.
See this image and copyright information in PMC

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