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. 1989 Nov;101(4):429-42.
doi: 10.1016/0021-9975(89)90026-1.

Serial ultrastructural studies of scrapie in hamsters

P P Liberski  1 , D M Asher, R Yanagihara, C J Gibbs Jr, D C Gajdusek
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Serial ultrastructural studies of scrapie in hamsters

P P Liberski et al. J Comp Pathol. 1989 Nov.

Abstract

We report sequential studies of the ultrastructural neuropathology of the subcortical grey matter of hamsters infected with the 263K strain of scrapie virus. Vacuolation in this model develops relatively late in the incubation period, while tubulovesicular structures appear early. Furthermore, neuroaxonal dystrophy, accumulations of branching tubules, and neuronal change consisting of intracytoplasmic "whorls" of proliferating membranes constitute prominent features of scrapie-related neurodegeneration.

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