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Review
. 2015 Sep;54(9):1541-8.
doi: 10.1093/rheumatology/kev223. Epub 2015 Jun 11.

Renal involvement in primary Sjögren's syndrome

Rhys Evans  1 , Anselm Zdebik  1 , Coziana Ciurtin  2 , Stephen B Walsh  3
Affiliations
Free article
Review

Renal involvement in primary Sjögren's syndrome

Rhys Evans et al. Rheumatology (Oxford). 2015 Sep.
Free article

Abstract

SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.

Keywords: B cells; Fanconi syndrome; Sjögren’s syndrome; Th17 cells; autoantibodies; autoimmune epithelialitis; distal renal tubular acidosis; hypocomplementaemia; tubulointerstitial nephritis; vasculitis.

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