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Comment
. 2015 Jul;23(7):389-91.
doi: 10.1016/j.tim.2015.05.006. Epub 2015 Jun 9.

Infectious asthma triggers: time to revise the hygiene hypothesis?

Wilmore C Webley  1 , Kelly L Aldridge  2
Affiliations
Comment

Infectious asthma triggers: time to revise the hygiene hypothesis?

Wilmore C Webley et al. Trends Microbiol. 2015 Jul.

Abstract

The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later in life. This reignites discussions on infection-mediated asthma phenotypes and potential therapeutics.

Keywords: asthma; hygiene hypothesis; microbiome; respiratory infection.

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