Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1989 Oct;4(4):313-22.
doi: 10.1097/00004850-198910000-00006.

A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder

J B Cohn  1 , G Collins, E Ashbrook, J F Wernicke
Affiliations
Clinical Trial

A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder

J B Cohn et al. Int Clin Psychopharmacol. 1989 Oct.

Abstract

This was a 6-week, double-blind comparison of fluoxetine, imipramine, and placebo in 89 patients with bipolar depression. Using the criteria of greater than or equal to 50% improvement in the HAMD-total score after at least 3 weeks on study drug, endpoint analysis showed 86% of the fluoxetine-treated patients improved compared with 57% of the imipramine-treated and 38% of the placebo-treated patients. Significantly fewer fluoxetine-treated patients discontinued due to adverse events than did imipramine-treated patients (7% vs. 30%, respectively).

PubMed Disclaimer