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. 2015 Oct;92(4):298-300.
doi: 10.1016/j.contraception.2015.05.014. Epub 2015 Jun 10.

Serum adipocytokines and adipose weight gain: a pilot study in adolescent females initiating depot medroxyprogesterone acetate

Andrea E Bonny  1 , Hannah L H Lange  2 , Erinn M Hade  3 , Bram Kaufman  4 , Michael D Reed  5 , Sam Mesiano  6
Affiliations

Serum adipocytokines and adipose weight gain: a pilot study in adolescent females initiating depot medroxyprogesterone acetate

Andrea E Bonny et al. Contraception. 2015 Oct.

Abstract

Objective: To evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA).

Methods: Percent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified.

Results: Mean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months.

Conclusions: Serum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains.

Keywords: Adipocytokines; Adipose tissue; Adolescents; Depot medroxyprogesterone acetate; Weight gain.

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Conflict of interest statement

Conflict of Interest/Financial Disclosures: The authors have no conflicts of interest to disclose.

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