Reciprocal inhibition following lesions of the spinal cord in man

Abstract

1. Reciprocal inhibition was studied in normal subjects and patients with spinal cord lesions by stimulating the posterior tibial nerve below the threshold of the soleus alpha-motoneurone axons and recording the changes in firing probability of single tibialis anterior motor units activated by voluntary contraction. A short-latency (about 35 ms) period of decreased firing probability was assumed to represent reciprocal inhibition. 2. For a given stimulus intensity this inhibition was greater in patients with spinal lesions than in normal subjects. 3. The stimulus intensities at which soleus motoneurones and the Ia inhibitory interneurones were brought to threshold provided an estimate of the relative excitability of these two neural populations. In the patients with spinal lesions the Ia inhibitory interneurones were more excitable than soleus motoneurones, whereas in normal subjects the excitabilities were approximately equal. 4. Stimulation of the posterior tibial nerve below the threshold of alpha-motoneurone axons also resulted in a second period of inhibition with a latency of approximately 50 ms. This was less prominent in the patients with spinal cord lesions. 5. It is concluded that transmission through the pathways mediating reciprocal inhibition of flexor muscles during their voluntary contraction is enhanced following a spinal cord lesion in man but that a later inhibitory process is depressed.