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Review
. 2015 Jan;13(1):71-88.
doi: 10.2174/1570159X13666141210215655.

Caffeine: cognitive and physical performance enhancer or psychoactive drug?

Simone Cappelletti  1 , Daria Piacentino, Gabriele Sani  2 , Mariarosaria Aromatario  1
Affiliations
Review

Caffeine: cognitive and physical performance enhancer or psychoactive drug?

Simone Cappelletti et al. Curr Neuropharmacol. 2015 Jan.

Erratum in

  • Curr Neuropharmacol. 2015;13(4):554. Daria, Piacentino [corrected to Piacentino, Daria]

Abstract

Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic and chronotropic effects, and the central nervous system, with their locomotor activity stimulation and anxiogenic-like effects. Thus, it is of interest to examine whether these effects could be detrimental for health. Furthermore, caffeine abuse and dependence are becoming more and more common and can lead to caffeine intoxication, which puts individuals at risk for premature and unnatural death. The present review summarizes the main findings concerning caffeine's mechanisms of action (focusing on adenosine antagonism, intracellular calcium mobilization, and phosphodiesterases inhibition), use, abuse, dependence, intoxication, and lethal effects. It also suggests that the concepts of toxic and lethal doses are relative, since doses below the toxic and/or lethal range may play a causal role in intoxication or death. This could be due to caffeine's interaction with other substances or to the individuals' preexisting metabolism alterations or diseases.

Keywords: Abuse; caffeine; coffee; dependence; energy drinks; safety doses; toxicity.

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References

    1. Lee R.A., Balick M.J. Rx: Caffeine. Explore (NY), 2006;2(1):55–59. doi: 10.1016/j.explore.2005.10.012. - DOI - PubMed
    1. Weinberg B.A., Bealer B. The World of Caffeine: The Science and Culture of the World's Most Popular Drug. New York: Routledge; 2001. pp. 1–41.
    1. Porciúncula LO, Sallaberry C, Mioranzza S, Botton PH Rosemberg DB. The Janus face of caffeine. Neurochem. Int. 2013;63(6):594–609. - PubMed
    1. Eskelinen M.H., Ngandu T., Tuomilehto J., Soininen H., Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J. Alzheimers Dis. 2009;16(1):85–91. doi: 10.3233/JAD-2009-0920. - DOI - PubMed
    1. Espinosa J., Rocha A., Nunes F., Costa M.S., Schein V., Kazlauckas V., Kalinine E., Souza D.O., Cunha R.A., Porciúncula L.O. Caffeine consumption prevents memory impairment, neuronal damage, and adenosine A2A receptors upregulation in the hippocampus of a rat model of sporadic dementia. J. Alzheimers Dis. 2013;34(2):509–518. doi: 10.3233/JAD-111982. - DOI - PubMed

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