Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:846045.
doi: 10.1155/2015/846045. Epub 2015 May 5.

New and emerging strategies in platelet-rich plasma application in musculoskeletal regenerative procedures: general overview on still open questions and outlook

Francesca Salamanna  1 , Francesca Veronesi  1 , Melania Maglio  2 , Elena Della Bella  3 , Maria Sartori  1 , Milena Fini  4
Affiliations
Review

New and emerging strategies in platelet-rich plasma application in musculoskeletal regenerative procedures: general overview on still open questions and outlook

Francesca Salamanna et al. Biomed Res Int. 2015.

Abstract

Despite its pervasive use, the clinical efficacy of platelet-rich plasma (PRP) therapy and the different mechanisms of action have yet to be established. This overview of the literature is focused on the role of PRP in bone, tendon, cartilage, and ligament tissue regeneration considering basic science literature deriving from in vitro and in vivo studies. Although this work provides evidence that numerous preclinical studies published within the last 10 years showed promising results concerning the application of PRP, many key questions remain unanswered and controversial results have arisen. Additional preclinical studies are needed to define the dosing, timing, and frequency of PRP injections, different techniques for delivery and location of delivery, optimal physiologic conditions for injections, and the concomitant use of recombinant proteins, cytokines, additional growth factors, biological scaffolds, and stems cells to develop optimal treatment protocols that can effectively treat various musculoskeletal conditions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic representation of the PubMed database searches.
Figure 2
Figure 2
An overview on the application of PRP in musculoskeletal regenerative procedures in the last decade.
See this image and copyright information in PMC

References

    1. Woolf A. D., Pfleger B. Burden of major musculoskeletal conditions. Bulletin of the World Health Organization. 2003;81(9):646–656. - PMC - PubMed
    1. Bitton R. The economic burden of osteoarthritis. The American Journal of Managed Care. 2009;15(8):S230–S235. - PubMed
    1. Burge R., Dawson-Hughes B., Solomon D. H., Wong J. B., King A., Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. Journal of Bone and Mineral Research. 2007;22(3):465–475. doi: 10.1359/jbmr.061113. - DOI - PubMed
    1. Frobell R. B., Lohmander L. S., Roos H. P. Acute rotational trauma to the knee: Poor agreement between clinical assessment and magnetic resonance imaging findings. Scandinavian Journal of Medicine & Science in Sports. 2007;17(2):109–114. doi: 10.1111/j.1600-0838.2006.00559.x. - DOI - PubMed
    1. Clayton R. A. E., Court-Brown C. M. The epidemiology of musculoskeletal tendinous and ligamentous injuries. Injury. 2008;39(12):1338–1344. doi: 10.1016/j.injury.2008.06.021. - DOI - PubMed

Publication types