Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2015 Jun 15;10(6):e0129927.
doi: 10.1371/journal.pone.0129927. eCollection 2015.

Similar Occurrence of Febrile Episodes Reported in Non-Atopic Children at Three to Five Years of Age after Prebiotics Supplemented Infant Formula

Margriet van Stuijvenberg  1 , José Stam  1 , Christoph Grüber  2 , Fabio Mosca  3 , Sertac Arslanoglu  4 , Gaetano Chirico  5 , Christian P Braegger  6 , Josef Riedler  7 , Günther Boehm  8 , Pieter J J Sauer  1 ; Multicentre Immuno Programming Study (MIPS) Study Group
Collaborators, Affiliations
Randomized Controlled Trial

Similar Occurrence of Febrile Episodes Reported in Non-Atopic Children at Three to Five Years of Age after Prebiotics Supplemented Infant Formula

Margriet van Stuijvenberg et al. PLoS One. .

Abstract

This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: GB was a member of the scientific board of Danone Reseach and received payment, CG has received honorarium for presentations from Danone Research and CPB, PJJS and JR have been members of the advisory board with Danone Research. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Flow diagram.
See this image and copyright information in PMC

References

    1. Wilson AC, Forsyth JS, Greene SA, Irvine L, Hau C, Howie PW. Relation of infant diet to childhood health: seven year follow up of cohort of children in Dundee infant feeding study. BMJ 1998;316:21–25. - PMC - PubMed
    1. Yu ZT, Chen C, Kling DE, Liu B, McCoy JM, Merighi M, et al. The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota. Glycobiology 2013;23;169–177. 10.1093/glycob/cws138 - DOI - PMC - PubMed
    1. Morrow AL, Ruiz-Palacios GM, Altaye M, Jiang X, Guerrero ML, Meinzen-Derr JK, et al. Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. J Pediatr 2004;145:297–303. - PubMed
    1. Bakker-Zierikzee AM, Alles MS, Knol J, Kok FJ, Tolboom JJM, Bindels JG. Effect of infant formulas containing prebiotics or probiotics on the intestinal flora during the first months of life. J Nutr 2005;94:783–790. Dundee infant feeding study. - PubMed
    1. Eiwegger T, Stahl B, Schmitt J, Boehm G, Gerstmayr M, Pichler J, et al. Human milk derived oligosaccharides and plant derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res 2004;56: 536–40. - PubMed

Publication types