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Case Reports
. 2015 Feb 4:12:23-6.
doi: 10.1016/j.gore.2014.12.004. eCollection 2015 Apr.

Metronomic cyclophosphamide with bevacizumab provides disease stabilization in patients with advanced uterine cancer

Ioannis Alagkiozidis  1 , Melissa Lozano  1 , Mithun Devraj  1 , Yi-Chun Lee  1 , Ovadia Abulafia  1
Affiliations
Case Reports

Metronomic cyclophosphamide with bevacizumab provides disease stabilization in patients with advanced uterine cancer

Ioannis Alagkiozidis et al. Gynecol Oncol Rep. .

Abstract

•We present two cases of advanced uterine cancer that were treated with the combination of metronomic cyclophosphamide and bevacizumab.•Targeting angiogenesis can provide disease control in patients with advanced uterine cancer.•Randomized controlled trials comparing metronomic and conventional regimens in advanced uterine cancer are required.

Keywords: Bevacizumab; Cyclophosphamide; Endometrioid; Metronomic.

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Figures

Fig. 1
Fig. 1
A. CT Abdomen shows multiple metastatic lesions (left). Stable metastatic liver lesions after 12 months of treatment with metronomic cyclophosphamide and bevacizumab (right). B. Disease stabilization with metronomic cyclophosphamide and bevacizumab in patient with advanced endometrioid adenocarcinoma as evidenced by CA-125 levels.
Fig. 2
Fig. 2
Disease stabilization with metronomic cyclophosphamide and bevacizumab in a patient with UPSC as evidenced by CA-125 levels.
See this image and copyright information in PMC

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