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. 2015 Sep;9(3):291-6.
doi: 10.1007/s12079-015-0297-3. Epub 2015 Jun 16.

A knowledgebase resource for interleukin-17 family mediated signaling

Jyoti Sharma  1   2 , Lavanya Balakrishnan  3 , Keshava K Datta  4   5 , Nandini A Sahasrabuddhe  6 , Aafaque Ahmad Khan  7   8 , Apeksha Sahu  9   10 , Anish Singhal  11   12 , Derese Getnet  13 , Rajesh Raju  14   15 , Aditi Chatterjee  16   17 , Harsha Gowda  18   19 , T S Keshava Prasad  20   21 , Subramanian Shankar  22 , Akhilesh Pandey  23
Affiliations

A knowledgebase resource for interleukin-17 family mediated signaling

Jyoti Sharma et al. J Cell Commun Signal. 2015 Sep.

Abstract

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.

Keywords: Activation; Differential expression; Inhibition; NetPath; Post-translational modifications; Protein-protein interaction; Translocation.

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Figures

Fig. 1
Fig. 1
A schematic representation of reactions induced by IL-17. The pathway reaction map depicts molecules involved in molecular associations, catalysis, and translocation events induced upon treatment with IL-17 ligand family. Site and residues of post-translational modifications are also mentioned, wherever available. Upon stimulation of IL-17, important signaling pathways including PI3K-AKT, Ras-MAPK, and NFκB are found to be activated
See this image and copyright information in PMC

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