Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar 1;50(1):27-36.
doi: 10.5152/tpa.2015.2167. eCollection 2015 Mar.

Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: short term results

Aytuğ Atıcı  1 , Yalçın Çelik  1 , Selvi Gülaşı  1 , Ali Haydar Turhan  1 , Çetin Okuyaz  2 , Mehmet Ali Sungur  3
Affiliations

Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: short term results

Aytuğ Atıcı et al. Turk Pediatri Ars. .

Abstract

Aim: In this study, it was aimed to investigate which method was superior by applying selective head cooling or whole body cooling therapy in newborns diagnosed with moderate or severe hypoxic ischemic encephalopathy.

Materials and method: Newborns above the 35th gestational age diagnosed with moderate or severe hypoxic ischemic encephalopathy were included in the study and selective head cooling or whole body cooling therapy was performed randomly. The newborns who were treated by both methods were compared in terms of adverse effects in the early stage and in terms of short-term results. Ethics committee approval was obtained for the study (06.01.2010/35).

Results: Fifty three babies diagnosed with hypoxic ischemic encephalopathy were studied. Selective head cooling was applied to 17 babies and whole body cooling was applied to 12 babies. There was no significant difference in terms of adverse effects related to cooling therapy between the two groups. When the short-term results were examined, it was found that the hospitalization time was 34 (7-65) days in the selective head cooling group and 18 (7-57) days in the whole body cooling group and there was no significant difference between the two groups (p=0.097). Four patients in the selective head cooling group and two patients in the whole body cooling group were discharged with tracheostomy because of the need for prolonged mechanical ventilation and there was no difference between the groups in terms of discharge with tracheostomy (p=0.528). Five patients in the selective head cooling group and three patients in the whole body cooling group were discharged with a gastrostomy tube because they could not be fed orally and there was no difference between the groups in terms of discharge with a gastrostomy tube (p=0.586). One patient who was applied selective head cooling and one patient who was applied whole body cooling died during hospitalization and there was no difference between the groups in terms of mortality (p=0.665).

Conclusions: There is no difference between the methods of selective head cooling and whole body cooling in terms of adverse effects and short-term results.

Keywords: Hypoxic ischemic encephalopathy; selective head cooling; whole body cooling.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Flowchart showing enrollment of the patients and randomization into groups (SHC. Selective head cooling; WBC: whole body cooling)
Figure 2.
Figure 2.
Variation of the rectal, skin and head temperature by time in the newborns who were applied selective head cooling
Figure 3.
Figure 3.
Variation of the rectal and skin temperature by time in the newborns who were applied whole body cooling
See this image and copyright information in PMC

References

    1. Gardiner J, Wagh D, McMichael J, Hakeem M, Rao S. Outcomes of hypoxic ischaemic encephalopathy treated with therapeutic hypothermia using cool gel packs experience from Western Australia. Eur J Paediatr Neurol. 2014:391–8. http://dx.doi.org/10.1016/j.ejpn.2014.02.003. - DOI - PubMed
    1. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;(1):CD003311. doi: 10.1002/14651858. Art No: CD003311. Pub3. http://dx.doi.org/10.1002/14651858. - DOI - DOI - PMC - PubMed
    1. Takenouchi T, Iwata O, Nabetani M, Tamura M. Therapeutic hypothermia for neonatal encephalopathy: JSPNM & MHLW Japan working group practice guidelines consensus statement from the working group on therapeutic hypothermia for neonatal encephalopathy, Ministry of Health, Labor and Welfare (MHLW), Japan, and Japan Society for Perinatal and Neonatal Medicine (JSPNM) Brain Dev. 2012;34:165–70. http://dx.doi.org/10.1016/j.braindev.2011.06.009. - DOI - PubMed
    1. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663–70. http://dx.doi.org/10.1016/S0140-6736(05)17946-X. - DOI - PubMed
    1. Al-Macki N, Miller SP, Hall N, Shevell M. The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia. Pediatr Neurol. 2009;41:399–405. http://dx.doi.org/10.1016/j.pediatrneurol.2009.06.001. - DOI - PubMed

LinkOut - more resources