Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2015;9(6):563-75.
doi: 10.2217/bmm.15.21.

Serum biomarkers predictive of pre-eclampsia

Swati Anand  1 , Tanielle Mei Bench Alvarez  1 , W Evan Johnson  2 , M Sean Esplin  3   4 , Karen Merrell  1 , T Flint Porter  3   4 , Steven W Graves  1
Affiliations
Clinical Trial

Serum biomarkers predictive of pre-eclampsia

Swati Anand et al. Biomark Med. 2015.

Abstract

Aim: We sought serum biomarkers predictive of pre-eclampsia (PE).

Materials & methods: Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.

Results: Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).

Conclusions: Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.

Keywords: biomarkers; early diagnosis; pre-eclampsia; serum proteomics.

PubMed Disclaimer

Publication types

LinkOut - more resources