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. 2015 Jul;21(7):1101-6.
doi: 10.3201/eid2107.150138.

Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors

Jasper F W Chan, Thomas S Y Chan, Harinder Gill, Frank Y F Lam, Nigel J Trendell-Smith, Siddharth Sridhar, Herman Tse, Susanna K P Lau, Ivan F N Hung, Kwok-Yung Yuen, Patrick C Y Woo

Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors

Jasper F W Chan et al. Emerg Infect Dis. 2015 Jul.

Erratum in

  • Emerg Infect Dis. 2015 Oct;21(10):1877

Abstract

Infections with the fungus Talaromyces (formerly Penicillium) marneffei are rare in patients who do not have AIDS. We report disseminated T. marneffei infection in 4 hematology patients without AIDS who received targeted therapy with monoclonal antibodies against CD20 or kinase inhibitors during the past 2 years. Clinicians should be aware of this emerging complication, especially in patients from disease-endemic regions.

Keywords: CD20; Talaromyces (Penicillium) marneffei; fungi; kinase inhibitors; monoclonal antibodies; obinutuzumab; rituximab; ruxolitinib; sorafenib.

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Figures

Figure 1
Figure 1
Multiple, shallow, oozing ulcers at the terminal ileum (arrows) detected by colonoscopy on day 4 of hospitalization for case-patient 1, who had a disseminated infection with Talaromyces marneffei.
Figure 2
Figure 2
Nasopharyngeal biopsy specimen from case-patient 1, who had a disseminated infection with Talaromyces marneffei. A) Grocott silver staining showing abundant yeast cells (arrows) with central septa 4–5 µm in diameter. B) Hematoxylin and eosin staining showing necrotic material admixed with blood and fibrin with aggregates of foamy macrophages (arrow). Scale bars indicate 5 μm.
See this image and copyright information in PMC

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