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Editorial
. 2015 Jun;7(6):340-1.
doi: 10.18632/aging.100752.

Synergy between chemotherapy and cancer vaccination

Tetje C van der Sluis  1 , Sjoerd H van der Burg  2 , Cornelis J Melief  1   3
Affiliations
Editorial

Synergy between chemotherapy and cancer vaccination

Tetje C van der Sluis et al. Aging (Albany NY). 2015 Jun.
No abstract available

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Figures

Figure 1
Figure 1. Coordinated action of combined treatment with chemotherapy and vaccination
When a cancer patient is vaccinated with synthetic long peptides, these peptides are taken up, processed and presented by antigen presenting cells to T cells in the lymph node. These T cells proliferate and travel to the tumor where they recognize tumor antigen and produce effector molecules such as Granzyme B, IFN‐γ (pink circles) and TNFα (blue circles). At the same time, systemic chemotherapy treatment results in tumor cell death. Both individual treatments are rarely sufficient to cause complete tumor eradication. However, the combined action of TNFα and chemotherapy may result in synergistic cell death of tumor cells, resulting in enhanced survival of tumor bearing individuals.
See this image and copyright information in PMC

References

    1. Melief CJ, et al. Nat.Rev.Cancer. 2008;8:351–360. - PubMed
    1. van der Sluis TC, et al. Clin.Cancer Res. 2015;21:781–794. - PubMed
    1. Zhang B, et al. Kidney Int. 2007;72:37–44. - PubMed
    1. Eggermont AM, et al. Journal of Clinical Oncology. 1996;14:2653–2665. - PubMed
    1. Lejeune FJ, et al. Cancer Immun. 2006;6:6. - PubMed

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