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Case Reports
. 2015 Oct 15;61(8):1304-6.
doi: 10.1093/cid/civ474. Epub 2015 Jun 16.

Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

Jeffrey M Collins  1 , Kara Loren Raphael  2 , Charles Terry  2 , Emily J Cartwright  3 , Anjana Pillai  4 , Frank A Anania  5 , Monica M Farley  3
Affiliations
Case Reports

Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

Jeffrey M Collins et al. Clin Infect Dis. .

Abstract

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

Keywords: HBV reactivation; HBV/HCV coinfection; acute hepatitis; simeprevir; sofosbuvir.

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