Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Aug 3;14(15):2383-4.
doi: 10.1080/15384101.2015.1063292. Epub 2015 Jun 17.

The key roles of ERBB2 in cardiac regeneration

Gabriele D'Uva  1 , Eldad Tzahor
Affiliations
Editorial

The key roles of ERBB2 in cardiac regeneration

Gabriele D'Uva et al. Cell Cycle. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Transient activation of ERBB2 signaling as a strategy for heart regeneration. A schematic diagram of the role of ERBB2 in controlling post-natal cardiomyocyte proliferation and heart regeneration. ERBB2 levels diminish in cardiomyocytes during the first week after birth contributing to the cardiomyocyte cell cycle withdrawal. Transient induction of a constitutively active ERBB2 (caERBB2) in cardiomyocytes following myocardial infarction (MI) triggers cardiomyocyte dedifferentiation and proliferation as well as increased angiogenesis. Termination of the ERBB2 signaling facilitates cardiomyocyte re-differentiation leading to reduced scar formation and improved cardiac function.
See this image and copyright information in PMC

Comment on

References

    1. Porrello ER, et al.. Science 2011; 331:1078-80; PMID:21350179; http://dx.doi.org/10.1126/science.1200708 - DOI - PMC - PubMed
    1. Soonpaa MH, Field LJ. Circul Res 1998; 83:15-26; PMID:9670914; http://dx.doi.org/10.1161/01.RES.83.1.15 - DOI - PubMed
    1. Bersell K, et al.. Cell 2009; 138:257-70; PMID:19632177; http://dx.doi.org/10.1016/j.cell.2009.04.060 - DOI - PubMed
    1. Reuter S, et al.. PloS One 2014; 9:e115871; PMID:25545368; http://dx.doi.org/10.1371/journal.pone.0115871 - DOI - PMC - PubMed
    1. D'Uva G, et al.. Nat Cell Biol 2015; 17:627-38; PMID:25848746; http://dx.doi.org/10.1038/ncb3149 - DOI - PubMed

Substances