[Humoral factors in children with diabetes mellitus]

Abstract

Clinical and laboratory studies into the physiochemical properties of circulating immune complexes, serum IgA, IgM, IgG and antibodies against insulin contained by blood serum and circulating immune complexes were conducted in 102 children aged 7-14 years. Of these, 60 children were affected with insulin-dependent diabetes mellitus (IDDM) and 42 were normal. The data obtained point to the activity of autoimmune processes in IDDM patients in the first years of the disease, which manifested itself by the high content of circulating immune complexes and antibodies against insulin. The content of circulating immune complexes may serve an additional immunological indicator of compensation and prognosis of the disease.