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. 2016 Feb;22(2):245-9.
doi: 10.1177/1352458515590647. Epub 2015 Jun 17.

Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Enrico Fainardi  1 , Daria Bortolotti  2 , Silvia Bolzani  2 , Massimiliano Castellazzi  3 , Carmine Tamborino  3 , Gloria Roversi  3 , Eleonora Baldi  4 , Maria Luisa Caniatti  4 , Ilaria Casetta  3 , Valentina Gentili  2 , Enrico Granieri  3 , Roberta Rizzo  2 ; ERMES study group
Collaborators, Affiliations

Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis

Enrico Fainardi et al. Mult Scler. 2016 Feb.

Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown.

Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis.

Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls.

Results: CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001).

Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.

Keywords: CSF levels; HLA-G; MRI activity; Multiple Sclerosis; dimeric form.

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