Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jul;16(7):389-402.
doi: 10.1038/nrn3946.

Crosstalk between the nociceptive and immune systems in host defence and disease

Stephen B McMahon  1 , Federica La Russa  1 , David L H Bennett  2
Affiliations
Review

Crosstalk between the nociceptive and immune systems in host defence and disease

Stephen B McMahon et al. Nat Rev Neurosci. 2015 Jul.

Abstract

Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states.

PubMed Disclaimer

References

    1. Ann N Y Acad Sci. 2002 Jun;966:343-54 - PubMed
    1. Glia. 2014 May;62(5):692-708 - PubMed
    1. Regul Pept. 2007 Jun 7;141(1-3):44-54 - PubMed
    1. Neurosci Lett. 1993 Jul 23;157(2):167-70 - PubMed
    1. Int J Dermatol. 1990 Jul-Aug;29(6):418-20 - PubMed

Publication types

LinkOut - more resources