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Review
. 2015 Jun 8:9:985-94.
doi: 10.2147/OPTH.S59828. eCollection 2015.

Risk definition and management strategies in retinoblastoma: current perspectives

Fariba Ghassemi  1 , Alireza Khodabande  1
Affiliations
Review

Risk definition and management strategies in retinoblastoma: current perspectives

Fariba Ghassemi et al. Clin Ophthalmol. .

Abstract

This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatments of retinoblastoma. Presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Currently, globe-sparing therapies, including systemic chemotherapy, intra-arterial chemoreduction, intravitreal chemotherapy, focal consolidation, and combination therapies, are being used and investigated actively. Major advances are being made in the diagnosis and management of retinoblastoma that will lead to improved morbidity and mortality rates in patients with retinoblastoma. By saving the globes, fronting with some high-risk factors for metastasis would be inevitable. International multi-institutional prospective studies could resolve current uncertainties regarding the main tumor treatment regimens for each patient and indications for chemoprophylaxis for high-risk-factor-bearing retinoblastoma cases.

Keywords: intra-arterial chemotherapy; retinoblastoma; systemic chemotherapy.

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References

    1. Shields JA, Shields CL. Management and prognosis of retinoblastoma. In: Shields JA, Shields CL, editors. Intraocular Tumors. A Text and Atlas. Philadelphia: WB Saunders; 1992. pp. 377–392.
    1. Shields JA, Shields CL. Retinoblastoma. In: Shields JA, Shields CL, editors. Atlas of Intraocular Tumors. Philadelphia: Lippincott Williams Wilkins; 2008. pp. 293–365.
    1. MacCarthy A, Draper GJ, Steliarova-Foucher E, Kingston JE. Retinoblastoma incidence and survival in European children (1978–1997). Report from the automated childhood cancer information system project. Eur J Cancer. 2006;42(13):2092–2102. - PubMed
    1. Cavenee WK, Dryja TP, Phillips RA, et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature. 1983;305(5937):779–784. - PubMed
    1. Shields CL, Meadows AT, Leahey AM, Shields JA. Continuing challenges in the management of retinoblastoma with chemotherapy. Retina. 2004;24(6):849–862. - PubMed