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. 2015:2015:892671.
doi: 10.1155/2015/892671. Epub 2015 May 18.

Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain

Lenka Vinklárková  1 , Ruta Masteiková  1 , David Vetchý  1 , Petr Doležel  1 , Jurga Bernatonienė  2
Affiliations

Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain

Lenka Vinklárková et al. Biomed Res Int. 2015.

Abstract

Effective assessment and management of wound pain can facilitate both improvements in healing rates and overall quality of life. From a pharmacological perspective, topical application of nonsteroidal anti-inflammatory drugs in the form of film wound dressings may be a good choice. Thus, the aim of this work was to develop novel layered film wound dressings containing ibuprofen based on partially substituted fibrous sodium carboxymethylcellulose (nonwoven textile Hcel NaT). To this end, an innovative solvent casting method using a sequential coating technique has been applied. The concentration of ibuprofen which was incorporated as an acetone solution or as a suspension in a sodium carboxymethylcellulose dispersion was 0.5 mg/cm(2) and 1.0 mg/cm(2) of film. Results showed that developed films had adequate mechanical and swelling properties and an advantageous acidic surface pH for wound application. An in vitro drug release study implied that layered films retained the drug for a longer period of time and thus could minimize the frequency of changing the dressing. Films with suspended ibuprofen demonstrated higher drug content uniformity and superior in vitro drug release characteristics in comparison with ibuprofen incorporation as an acetone solution. Prepared films could be potential wound dressings for the effective treatment of wound pain in low exuding wounds.

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Figures

Figure 1
Figure 1
Microscopic appearance of NaCMC film without ibuprofen and Sanatyl: (a) magnification 20x, bar 500 μm; (b) magnification 50x, bar 100 μm.
Figure 2
Figure 2
Microscopic appearance of the film with suspended ibuprofen (0.5-Ibu-2 without Sanatyl): (a) magnification 7.5x, bar 1000 μm, (b) magnification 20x, bar 500 μm.
Figure 3
Figure 3
Microscopic appearance of the film with ibuprofen crystallized from acetone solution (0.5-Ibu-1 without Sanatyl): (a) magnification 7.5x, bar 1000 μm, (b) magnification 20x, bar 500 μm.
Figure 4
Figure 4
Microscopic appearance of the films with Sanatyl and the same concentration of ibuprofen (magnified 7.5x, bar 1000 μm): (a) film with suspended drug (0.5-Ibu-2), (b) film with drug incorporated as acetone solution (0.5-Ibu-1); arrows mark points where the thickness of films was measured.
Figure 5
Figure 5
Surface pH of the films with ibuprofen in the conditions simulating a wound environment.
Figure 6
Figure 6
Swelling behavior of prepared films.
Figure 7
Figure 7
Mechanical properties of films: work done during the process of measurement and deformation/elongation of film at the moment of tearing.
Figure 8
Figure 8
Box diagrams for the drug content uniformity: box encloses 50% of the data and the median as the center of the cross; the whiskers indicate the maximum or minimum value.
Figure 9
Figure 9
Release of ibuprofen from prepared films.
See this image and copyright information in PMC

References

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