Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun 19;10(6):e0131110.
doi: 10.1371/journal.pone.0131110. eCollection 2015.

Effect of Intraocular Forward Scattering and Corneal Higher-Order Aberrations on Visual Acuity after Descemet's Stripping Automated Endothelial Keratoplasty

Kazutaka Kamiya  1 , Hitomi Asato  1 , Kimiya Shimizu  1 , Hidenaga Kobashi  1 , Akihito Igarashi  1
Affiliations

Effect of Intraocular Forward Scattering and Corneal Higher-Order Aberrations on Visual Acuity after Descemet's Stripping Automated Endothelial Keratoplasty

Kazutaka Kamiya et al. PLoS One. .

Abstract

Purpose: To assess the relationship of intraocular forward scattering and corneal higher-order aberrations (HOAs) with best spectacle corrected visual acuity (BSCVA) after Descemet's stripping automated endothelial keratoplasty (DSAEK), and to compare these parameters between DSAEK and non-Descemet's stripping automated endothelial keratoplasty (n-DSAEK) groups.

Methods: This retrospective study enrolled thirty eyes of 30 consecutive patients who underwent standard DSAEK, and who underwent successful phacoemulsification with intraocular lens implantation before DSAEK. The mean age at the time of surgery was 71.7 ± 10.4 years. We quantitatively evaluated the objective scattering index (OSI) using the double-pass instrument (OQAS II, Visiometrics) and corneal HOAs using Hartmann-Shack aberrometry (KR-9000PW, Topcon) 3 months postoperatively.

Results: The mean OSI, corneal HOAs, and logMAR BSCVA 3 months after DSAEK were 7.91 ± 3.58, 0.43 ± 0.27 μm, and 0.32 ± 0.25, respectively. We found a significant correlation between the OSI and logMAR BSCVA (Spearman correlation coefficient r=0.714, p<0.001), but no significant association between corneal HOAs and logMAR BSCVA 3 months postoperatively (r=0.209, p=0.267). We found no significant differences in any postoperative parameters between the DSAEK and n-DSAEK groups (p>0.05).

Conclusions: Our pilot study demonstrated that the postoperative corrected visual acuity was significantly correlated with intraocular forward scattering, but not with corneal HOAs in post-DSAEK eyes, suggesting that intraocular forward scattering plays a more essential role in postoperative visual performance than corneal aberrations after DSAEK. The detailed visual performance, such as HOAs and intraocular scattering, after n-DSAEK appears to be essentially equivalent to that after DSAEK.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. A graph showing a significant correlation between the objective scattering index (OSI) and best spectacle corrected visual acuity (BSCVA) (Spearman correlation coefficient r = 0.714, p<0.001).
Fig 2
Fig 2. A graph showing no significant association between corneal higher-order aberrations and best spectacle corrected visual acuity (BSCVA) (Spearman correlation coefficient r = 0.209, p = 0.267).
Fig 3
Fig 3. The double-pass images of eyes undergoing Descemet’s stripping automated endothelial keratoplasty (DSAEK) and non-Descemet’s stripping automated endothelial keratoplasty (n-DSAEK).
MTF = modulation transfer function.
See this image and copyright information in PMC

References

    1. Price FW Jr, Price MO (2005) Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant. J Refract Surg.; 21:339–345. - PubMed
    1. Gorovoy MS (2006) Descemet-stripping automated endothelial keratoplasty. Cornea.; 25:886–889. - PubMed
    1. Price MO, Price FW (2007) Descemet's stripping endothelial keratoplasty. Curr Opin Ophthalmol.; 18:290–294. - PubMed
    1. Yamaguchi T, Negishi K, Yamaguchi K, Murat D, Uchino Y, Shimmura S, et al. (2009) Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty. J Cataract Refract Surg.; 35:688–694. 10.1016/j.jcrs.2008.11.062 - DOI - PubMed
    1. Muftuoglu O, Prasher P, Bowman RW, McCulley JP, Mootha VV (2010) Corneal higherorder aberrations after Descemet’s stripping automated endothelial keratoplasty. Ophthalmology.; 117:878–884. 10.1016/j.ophtha.2010.02.001 - DOI - PubMed

LinkOut - more resources