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Comment
. 2015 Jun 18;161(7):1492-3.
doi: 10.1016/j.cell.2015.06.006.

ER Stress in Dendritic Cells Promotes Cancer

Christopher S Garris  1 , Mikael J Pittet  2
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Free article
Comment

ER Stress in Dendritic Cells Promotes Cancer

Christopher S Garris et al. Cell. .
Free article

Abstract

XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.

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