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Comment
. 2015 Jun 18;161(7):1494-6.
doi: 10.1016/j.cell.2015.06.008.

Wnt Down, Tumors Wind Up?

Paul Krimpenfort  1 , Anton Berns  2
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Wnt Down, Tumors Wind Up?

Paul Krimpenfort et al. Cell. .
Free article

Abstract

In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an exquisite target for intervention.

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