A Shortcut to Activity-Dependent Transcription

Nikhil Sharma¹, Harrison W Gabel¹, Michael E Greenberg²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: meg@hms.harvard.edu.

PMID: 26091031
DOI: 10.1016/j.cell.2015.06.009

Comment

A Shortcut to Activity-Dependent Transcription

Nikhil Sharma et al. Cell. 2015.

. 2015 Jun 18;161(7):1496-8.

doi: 10.1016/j.cell.2015.06.009.

Authors

Nikhil Sharma¹, Harrison W Gabel¹, Michael E Greenberg²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: meg@hms.harvard.edu.

PMID: 26091031
DOI: 10.1016/j.cell.2015.06.009

Abstract

Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.

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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.
Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH. Madabhushi R, et al. Cell. 2015 Jun 18;161(7):1592-605. doi: 10.1016/j.cell.2015.05.032. Epub 2015 Jun 4. Cell. 2015. PMID: 26052046 Free PMC article.

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A Shortcut to Activity-Dependent Transcription

Affiliations

A Shortcut to Activity-Dependent Transcription

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms