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Comment
. 2015 Jun 18;161(7):1500-2.
doi: 10.1016/j.cell.2015.06.010.

Finding the Roots of Adult Neurogenesis

Mazen A Kheirbek  1
Affiliations
Comment

Finding the Roots of Adult Neurogenesis

Mazen A Kheirbek. Cell. .

Abstract

In select areas of the brain, neural stem cells produce new neurons throughout life. An elegant new study in this issue of Cell reveals the origins of a stem cell population that persists into adulthood and uncovers a surprising relationship between neurons born in the mature brain and those generated early in development.

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Figures

Figure 1
Figure 1. Using Genetic Barcodes to Tracethe Family Tree of Adult-Born Olfactory Neurons
Adult NSCs (B1-cells) arise from progenitors that give rise to specific subsets of forebrain neurons whose identity is defined by embryonic position of the RG cell early in development. This level of specificity generates a direct relationship between adult-born OB neurons and embryonically generated forebrain neurons. This “family tree” allows tracing the relationships between adult-born neurons and those born in utero.
See this image and copyright information in PMC

Comment on

  • Embryonic Origin of Postnatal Neural Stem Cells.
    Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A. Fuentealba LC, et al. Cell. 2015 Jun 18;161(7):1644-55. doi: 10.1016/j.cell.2015.05.041. Cell. 2015. PMID: 26091041 Free PMC article.

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