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Comment
. 2015 Jun 18;161(7):1502-4.
doi: 10.1016/j.cell.2015.06.005.

Linking Micronuclei to Chromosome Fragmentation

Emily M Hatch  1 , Martin W Hetzer  2
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Linking Micronuclei to Chromosome Fragmentation

Emily M Hatch et al. Cell. .
Free article

Abstract

Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.

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  • Chromothripsis from DNA damage in micronuclei.
    Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. Zhang CZ, et al. Nature. 2015 Jun 11;522(7555):179-84. doi: 10.1038/nature14493. Epub 2015 May 27. Nature. 2015. PMID: 26017310 Free PMC article.

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