Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2015 Jun 19;10(6):e0130412.
doi: 10.1371/journal.pone.0130412. eCollection 2015.

The Value of BISAP Score for Predicting Mortality and Severity in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Wei Gao  1 , Hong-Xia Yang  1 , Cheng-En Ma  1
Affiliations
Meta-Analysis

The Value of BISAP Score for Predicting Mortality and Severity in Acute Pancreatitis: A Systematic Review and Meta-Analysis

Wei Gao et al. PLoS One. .

Erratum in

Abstract

Purpose: The Bedside Index for Severity in Acute Pancreatitis (BISAP) score has been developed to identify patients at high risk for mortality or severe disease early during the course of acute pancreatitis. We aimed to undertake a meta-analysis to quantify the accuracy of BISAP score for predicting mortality and severe acute pancreatitis (SAP).

Materials and methods: We searched the databases of Pubmed, Embase, and the Cochrane Library to identify studies using the BISAP score to predict mortality or SAP. The pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratio (DOR) were calculated from each study and were compared with the traditional scoring systems.

Results: Twelve cohorts from 10 studies were included. The overall sensitivity of a BISAP score of ≥3 for mortality was 56% (95% CI, 53%-60%), with a specificity of 91% (95% CI, 90%-91%). The positive and negative likelihood ratios were 5.65 (95% CI, 4.23-7.55) and 0.48 (95% CI, 0.41-0.56), respectively. Regarding the outcome of SAP, the pooled sensitivity was 51% (43%-60%), and the specificity was 91% (89%-92%). The pooled positive and negative likelihood ratios were 7.23 (4.21-12.42) and 0.56 (0.44-0.71), respectively. Compared with BISAP score, the Ranson criteria and APACHEⅡscore showed higher sensitivity and lower specificity for both outcomes.

Conclusions: The BISAP score was a reliable tool to identify AP patients at high risk for unfavorable outcomes. Compared with the Ranson criteria and APACHEⅡscore, BISAP score outperformed in specificity, but having a suboptimal sensitivity for mortality as well as SAP.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The flowdiagram for study selection process.
Fig 2
Fig 2. Pooled sensitivity and specificity for BISAP score ≥3 in predicting mortality.
(A) Sensitivity; (B) specificity.
Fig 3
Fig 3. Summary of receiver operating characteristic curves of BISAP score for predicting mortality.
(A) BISAP ≥3; (B) BISAP ≥2.
Fig 4
Fig 4. Pooled sensitivity and specificity for BISAP score ≥2 in predicting mortality.
(A) Sensitivity; (B) specificity.
Fig 5
Fig 5. Pooled sensitivity and specificity for BISAP score ≥3 in predicting severe acute pancreatitis.
(A) Sensitivity; (B) specificity.
See this image and copyright information in PMC

References

    1. Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87 e1–3. 10.1053/j.gastro.2012.08.002 - DOI - PMC - PubMed
    1. Bakker OJ, Issa Y, van Santvoort HC, Besselink MG, Schepers NJ, Bruno MJ, et al. Treatment options for acute pancreatitis. Nature reviews Gastroenterology & hepatology. 2014;11(8):462–9. 10.1038/nrgastro.2014.39 . - DOI - PubMed
    1. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102–11. 10.1136/gutjnl-2012-302779 . - DOI - PubMed
    1. Tenner S, Baillie J, DeWitt J, Vege SS, American College of G. American College of Gastroenterology guideline: management of acute pancreatitis. The American journal of gastroenterology. 2013;108(9):1400–15; 16 10.1038/ajg.2013.218 . - DOI - PubMed
    1. Whitcomb DC. Clinical practice. Acute pancreatitis. The New England journal of medicine. 2006;354(20):2142–50. 10.1056/NEJMcp054958 . - DOI - PubMed