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Comment
. 2015 Aug;21(8):463-5.
doi: 10.1016/j.molmed.2015.05.007. Epub 2015 Jun 16.

Radiotherapy and immune checkpoint blockade: potential interactions and future directions

David C Binder  1 , Yang-Xin Fu  2 , Ralph R Weichselbaum  3
Affiliations
Comment

Radiotherapy and immune checkpoint blockade: potential interactions and future directions

David C Binder et al. Trends Mol Med. 2015 Aug.

Abstract

Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.

Keywords: cancer; immunotherapy; radiation.

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  • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
    Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ. Twyman-Saint Victor C, et al. Nature. 2015 Apr 16;520(7547):373-7. doi: 10.1038/nature14292. Epub 2015 Mar 9. Nature. 2015. PMID: 25754329 Free PMC article.

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