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Randomized Controlled Trial
. 2015 Jul;102(8):972-8; discussion 978.
doi: 10.1002/bjs.9811.

Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer

D Pettersson  1 , E Lörinc  2 , T Holm  1 , H Iversen  1 , B Cedermark  1 , B Glimelius  2   3 , A Martling  1
Affiliations
Randomized Controlled Trial

Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer

D Pettersson et al. Br J Surg. 2015 Jul.

Abstract

Background: The Stockholm III Trial randomized patients with primary operable rectal cancers to either short-course radiotherapy (RT) with immediate surgery (SRT), short-course RT with surgery delayed 4-8 weeks (SRT-delay) or long-course RT with surgery delayed 4-8 weeks. This preplanned interim analysis examined the pathological outcome of delaying surgery.

Methods: Patients randomized to the SRT and SRT-delay arms in the Stockholm III Trial between October 1998 and November 2010 were included, and data were collected in a prospective register. Additional data regarding tumour regression grade, according to Dworak, and circumferential margin were obtained by reassessment of histopathological slides.

Results: A total of 462 of 545 randomized patients had specimens available for reassessment. Patients randomized to SRT-delay had earlier ypT categories, and a higher rate of pathological complete responses (11·8 versus 1·7 per cent; P = 0·001) and Dworak grade 4 tumour regression (10·1 versus 1·7 per cent; P < 0·001) than patients randomized to SRT without delay. Positive circumferential resection margins were uncommon (6·3 per cent) and rates did not differ between the two treatment arms.

Conclusion: Short-course RT induces tumour downstaging if surgery is performed after an interval of 4-8 weeks.

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Figures

Figure 1
Figure 1
Flow diagram of randomization to the Stockholm III Trial, and patient selection to the present study of the trial arms with short‐course radiotherapy (RT) with immediate surgery (SRT) and short‐course RT with surgery delayed 4–8 weeks (SRT‐delay). The trial arm with long‐course RT and surgery delayed 4–8 weeks (LRT‐delay) was not analysed in the present study
See this image and copyright information in PMC

Comment in

References

    1. Peeters KC, Marijnen CA, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T et al The TME trial after a median follow‐up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007; 246: 693–701. - PubMed
    1. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T et al Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001; 345: 638–646. - PubMed
    1. Pahlman L, Glimelius B. Pre‐ or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial. Ann Surg 1990; 211: 187–195. - PMC - PubMed
    1. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial [see comments]. N Engl J Med 1997; 336: 980–987 - PubMed
    2. [published erratum appears in N Engl J Med 1997; 336: 1539].
    1. Martling A, Holm T, Johansson H, Rutqvist L, Cedermark B. The Stockholm II trial on preoperative radiotherapy in rectal carcinoma. Cancer 2001; 92: 896–902. - PubMed

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