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Review
. 2015;35(6):600-4.
doi: 10.3109/10799893.2015.1030412. Epub 2015 Jun 22.

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu Sun  1 , Wen-Zhou Liu  1 , Tao Liu  1 , Xu Feng  1 , Nuo Yang  1 , Hua-Fu Zhou  1
Affiliations
Review

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

Yu Sun et al. J Recept Signal Transduct Res. 2015.

Abstract

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.

Keywords: Extracellular signal-regulated kinase; mitogen-activated protein kinases; signaling pathway.

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