Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2015 Dec;57(6):1116-20.
doi: 10.1111/ped.12733. Epub 2015 Nov 5.

Recurrent Kawasaki disease: USA and Japan

Ryan A Maddox  1 , Robert C Holman  1 , Ritei Uehara  2 , Laura S Callinan  1 , Jodie L Guest  3   4 , Lawrence B Schonberger  1 , Yosikazu Nakamura  5 , Mayumi Yashiro  5 , Ermias D Belay  1
Affiliations
Multicenter Study

Recurrent Kawasaki disease: USA and Japan

Ryan A Maddox et al. Pediatr Int. 2015 Dec.

Abstract

Background: Descriptive epidemiologic studies of recurrent and non-recurrent Kawasaki disease (KD) may identify other potentially important differences between these illnesses.

Methods: Data from the USA and Japan, the Centers for Disease Control and Prevention (CDC) national KD surveillance(1984-2008) and the 17th Japanese nationwide survey (2001-2002), respectively, were analyzed to examine recurrent KD patients <18 years of age meeting the CDC KD case or atypical KD case definition. These patients were compared with non-recurrent KD patients.

Results: Of the 5557 US KD patients <18 years of age during 1984-2008, 97 (1.7%) were identified as having had recurrent KD. Among the US Asian/Pacific Islander KD patients, 3.5% had recurrent KD, which was similar to the percentage identified among KD patients (3.5%) in the Japanese survey. Compared with non-recurrent KD patients, KD patients [with recurrent KD] were more likely to be older, fulfill the atypical KD case definition, and have coronary artery abnormalities (CAA) despite i.v. immunoglobulin (IVIG) treatment.

Conclusions: Differences in the age, race, and frequency of CAA exist between recurrent and non-recurrent KD patients. The increased association of CAA with recurrent KD suggests that more aggressive treatment strategies in conjunction with IVIG may be indicated for the second episode of KD.

Keywords: Kawasaki disease; Kawasaki syndrome; epidemiology; mucocutaneous lymph node syndrome; recurrence.

PubMed Disclaimer

References

    1. Belay ED, Holman RC, Clarke MJ, et al. The incidence of Kawasaki syndrome in West Coast health maintenance organizations. Pediatr Infect Dis J. 2000;19(9):828–32. - PubMed
    1. Belay ED, Maddox RA, Holman RC, Curns AT, Ballah K, Schonberger LB. Kawasaki syndrome and risk factors for coronary artery abnormalities, United States, 1994–2003. Pediatr Infect Dis J. 2006;25(3):245–9. - PubMed
    1. Holman RC, Curns AT, Belay ED, Steiner CA, Schonberger LB. Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics. 2003;112(3):495–501. - PubMed
    1. Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the committee on rheumatic fever, endocarditis and Kawasaki disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110:2747–71. - PubMed
    1. Nakamura Y, Yanagawa H. The worldwide epidemiology of Kawasaki disease. Prog Pediatr Cardiol. 2004;19(2):99–108.

Publication types

LinkOut - more resources